Gastroesophageal reflux disease (GERD) is a chronic and highly prevalent disorder caused by repeated reflux of gastric contents into the esophagus.

GERD is characterized by a wide variety of symptoms:

  • Heartburn and acid regurgitation are the most reported symptoms1
  • These symptoms significantly affect patients’ quality of life and work productivity2

The most common phenotypic presentations of GERD include non-erosive reflux disease (NERD) and erosive esophagitis (EE):3

  • EE is usually clinically differentiated from NERD by the presence of mucosal inflammation and lesions in the distal esophagus3,4
  • Additional reflux-monitoring studies may be performed to establish the extent of abnormal esophageal acid exposure1,3


The U.S. prevalence of GERD has been estimated at approximately 20%, or 65.7M individuals (based on current census data). As many as 60% to 70% of these patients are NERD patients. That means they have symptoms, but no visible EE during endoscopy.3-6

While proton pump inhibitors (PPIs) are the mainstay of therapy for GERD, 35% to 54% of patients fail to achieve complete relief of symptoms. This represents a large unmet and underappreciated patient need.1,3,7

Pipeline Products:


1. Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2022;117(1):27-56. doi:10.14309/ajg.0000000000001538

2. Tack J, Becher A, Mulligan C, et al. Systematic review: the burden of disruptive gastro-oesophageal reflux disease on health-related quality of life. Aliment Pharmacol Ther. 2012;35(11):1257-1266. doi: 10.1111/j.1365-2036.2012.05086

3. Fass R. Gastroesophageal Reflux Disease. N Engl J Med. 2022 Sep 29;387(13):1207-1216. doi: 10.1056/NEJMcp2114026. PMID: 36170502.

4. Hershcovici T, Fass R. Nonerosive reflux disease (NERD)—an update. J Neurogastroenterol Motil. 2010;16(1):8-21. doi:10.5056/jnm.2010.16.1.8

5. El-Serag HB, Sweet S, Winchester CC, et al. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63(6):871-880. doi: 10.1136/gutjnl-2012-304269

6. US Census Bureau 2020. Quick facts. Available at Accessed August 15, 2022.

7. Chey WD, Mody RR, Izat E. Patient and physician satisfaction with proton pump inhibitors (PPIs): are there opportunities for improvement? Dig Dis Sci. 2010;55(12):3415-3422. doi: 10.1007/ s10620-010-1209-2